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Ciprofloxacin dose dependent in macrophages. The effect of dapsone (1 mg/kg) on Caco-2 macrophages was studied. Mice were given a single intravenous injection of 10 mg/kg dapsone (dapsone, 1 mg/kg) or vehicle (PBS) and were observed to produce anti-inflammatory cytokines. Dapsone induced an increase in interleukin 6 generic ultram price (IL-6) and 10 (IL-10) as Order generic tramadol online well in interleukin-2 (IL-2) and interleukin-4 (IL-4) expression. health pharmacy online discount code Caco-2 macrophages from mice treated with dapsone exhibited significant increase in IL-6 secretion compared with Caco-2 macrophages from control mice. However, dapsone induced a significant buy generic ultram online increase in IL-12p70 (IL-12p70p70) expression. addition, dapsone treatment caused an upregulation in IFN-γ production (p<0.05). Interestingly, dapsone treatment also caused an increase in IL-17A (p<0.01) and mRNA levels in Caco-2 macrophages. Furthermore, dapsone treatment induced an increase in IL-12p70p70 mRNA as well IL-12p70 levels (p<0.05). These results indicate that dapsone has potent anti-inflammatory effects on Caco-2 macrophages through upregulation of IFN-γ expression and downregulation IL-12, IL-17 IL-17A mRNA expression.
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